Since its founding in 1988, NUCDF has relied on a core team of medical professionals with expertise in research and the many clinical care specialties related to urea cycle disorders.

Getting kids to take medicines can be a challenging task. Here are some strategies that may help make the process easier.

For families with children diagnosed with urea cycle disorders, life becomes a delicate balance of medical management, emotional resilience, and unwavering support.

By exploiting the technology used in Covid-19 vaccines, a team has created an effective therapy for arginosuccinic aciduria in a study in mice, demonstrating the technology’s potential therapeutic use in people.

A research team exploring the inheritance patterns of late-onset ornithine transcarbamylase deficiency (OTCD) has described two families showing father-to-daughter transmission of the disorder.

A research team has developed a method using yeast genetics to rapidly measure the effects of thousands of variants of a gene that causes human disease, with the aim of improving diagnosis of urea cycle disorders.

Experts from the Urea Cycle Disorders Consortium and the National Urea Cycle Disorders Foundation share what they're learning from the “Longitudinal Study of Urea Cycle Disorders.”

New research finds that the nitric oxide deficiencies common in arginosuccinate lyase deficiency (ASLD) create problems with the blood brain barrier, which is essential to maintaining brain health.

New research explores faster and more accurate diagnosis of urea cycle disorders (UCD), variants of uncertain significance, life with a UCD, and more.

Washington, D.C. – Following unanimous support in the Texas House of Representatives and a 30-1 vote in the Senate, Texas Governor Abbott affirmed the state's status as a leader in newborn screening by signing House Bill 2478 into law.

Five months after his death, Robbie Roper's family reveals that his tragic passing was caused by an undiagnosed urea cycle disorder. Robbie received corticosteroids - a known trigger for hyperammonemia - during shoulder surgery, leading to fatal hyperammonemia.

NUCDF and the Rare Diseases Clinical Research Network Urea Cycle Disorders Consortium (UCDC) partner to advance research. Read more about the partnership and current research studies.

NUCDF and the Rare Diseases Clinical Research Network Urea Cycle Disorders Consortium (UCDC)co-host the 5th International Scientific Symposium on Urea Cycle Disorders, "Mapping Progress: Current Concepts and New Insights in Urea Cycle Disorders," on September 22-24, 2021. Read more.

UCD experts, Brendan Lee M.D. Ph.D., Sandesh Nagamani M.D., and Andrea Gropman M.D., provide general guidance about COVID-19 vaccines in individuals with UCD and answer questions submitted by our UCD community. Presented in partnership by NUCDF and the NIH Rare Diseases Clinical Research Network Urea Cycle Disorders Consortium (UCDC).

Dr. Maria Elena Bottazzi, internationally-recognized vaccinologist, provides information and answers questions from our UCD community about the development and types of current vaccines, safety and effectiveness. Presented in partnership by NUCDF and the NIH Rare Diseases Clinical Research Network Urea Cycle Disorders Consortium (UCDC).

UCD warrior Jackson Fukuda has won the Rare Artist Award as part of Rare Disease Day

Raising awareness of UCDs on Rare Disease Day

Swift identification of elevated ammonia levels in the ER is needed to save lives. An affected family has partnered with NUCDF to raise awareness and educate medical professionals on the need to obtain blood ammonia levels.

Body builder Meegan Hefford has died from hyperammonemia from undiagnosed OTC deficiency.

The long-awaited clinical trial "Effect of Nitric Oxide Supplementation on Neurocognitive Functions in Patients With Argininosuccinate Lyase Deficiency/Argininosuccinic Aciduria (ASLD/ASA)" is now open for enrollment at Baylor College of Medicine (one of the UCD Research Consortium clinical research sites) in Houston, Texas.

A young college student has died from undiagnosed OTC deficiency.

Pharmaceutical industry sponsored clinical trial recruiting participants to test safety and effectiveness of enzyme replacement therapy for Arginase Deficiency.

NUCDF funds two new UCD clinical research sites at Stanford/Lucile Packard Children's and University of California San Francisco.