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We know Urea Cycle Disorders. We live to conquer them.

The National Urea Cycle Disorders Foundation is the only nonprofit organization in the world solely dedicated to saving and improving the lives of children and adults from the catastrophic effects of urea cycle disorders. Formed in 1988 by a handful of parents whose children were affected, NUCDF has grown to be an internationally recognized leader in the fight to conquer urea cycle disorders (UCD) and raise awareness that saves lives. NUCDF is the driving force behind critical research to improve the understanding and management of UCD, find new treatments, and ultimately a cure. NUCDF serves as a lifeline to UCD patients, families, and medical professionals worldwide seeking information, support, and HOPE. Learn more and get involved.

TOGETHER, WE CAN CONQUER UCD. COME JOIN US!

  • NUCDF is thrilled to bring the UCD community together at our Family Conference coming Spring/Summer 2024.

  • New UCD Research App Now Available!
    NUCDF is proud to announce the launch of a new app to inform the UCD community—families and providers—about the results of the Liver Transplant vs. Medical Management for Urea Cycle Disorders study.

  • NUCDF believes that it is critical to invest in clinical research infrastructure to enable us to find safe and effective treatments for UCDs, ensure patient access to expert care, and accomplish our ultimate goal of a cure.

  • Zoey's Story - Dedicated to Raising Awareness about Urea Cycle Disorders

  • Mitchell's Story of a Rare Genetic Disorder and Clinical Trials Participation

News

November 28, 2023

Experts from the Urea Cycle Disorders Consortium and the National Urea Cycle Disorders Foundation share what they're learning from the “Longitudinal Study of Urea Cycle Disorders.”

October 23, 2023

New research finds that the nitric oxide deficiencies common in arginosuccinate lyase deficiency (ASLD) create problems with the blood brain barrier, which is essential to maintaining brain health.

October 4, 2023

New research explores faster and more accurate diagnosis of urea cycle disorders (UCD), variants of uncertain significance, life with a UCD, and more.

 

 

  • James A. Bartley, M.D., Ph.D., * Associate Clinical Professor of Pediatrics, Division of Human Genetics, UC Irvine Medical Center
    James A. Bartley, M.D., Ph.D., * Associate Clinical Professor of Pediatrics, Division of Human Genetics, UC Irvine Medical Center

    NUCDF is the driving force in raising awareness of urea cycle disorders in the medical community throughout the United States. The NUCDF has led the way in shortening the time between onset of symptoms and the time of diagnosis of a urea cycle disorder. I have witnessed the increased hope and confidence of parents in caring for children with urea cycle disorders after the family has contacted the NUCDF.

Our Impact

For the past 30 years, NUCDF has been the driving force for raising awareness of UCD, improving diagnosis and treatment, and catalyzing pioneering research that saves and improves the lives of infants, children and adults with urea cycle disorders. Our donors make it all possible. Take a look at the impact your support can make.

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NUCDF Partnerships, Memberships and Recognitions:

  • UCDC RDCRN Logo
  • CPAG Logo
  • GreatNonprofits Top Rated
  • Guidestar_Candid Platinum 2022
  • Child Neurology Foundation Advocacy Award

    Child Neurology Foundation Advocacy Award

  • Nord Membership
    Nord Membership
  • Guidstar Platium 2021
    Guidstar Platium 2021
  • Genetic Alliance
    Genetic Alliance

  • Citrin Logo

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